학술논문
Sociodemographic and clinical characteristics of patients with borderline personality disorder enrolled for a first episode psychosis within a specialized "early intervention" service.
Document Type
Article
Author
Source
Subject
*Substance abuse
*Behavior disorders
*Self-injurious behavior
*Early medical intervention
*Hospital care
*Symptoms
*Antipsychotic agents
*Anxiety
*Disease prevalence
*Borderline personality disorder
*Longitudinal method
*Kaplan-Meier estimator
*Log-rank test
*Suicidal behavior
*Sociodemographic factors
*Psychoses
*Comparative studies
*Mental depression
*Comorbidity
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Language
ISSN
0020-7411
Abstract
Borderline Personality Disorder (BPD) is under-recognized in First Episode Psychosis (FEP). The aims of this investigation were: (a) to examine the prevalence of BPD in FEP patients enrolled within an Italian "Early Intervention in Psychosis" (EIP) service; (2) to compare sociodemographic, clinical and treatment characteristics at entry between FEP individuals with and without BPD; and (3) to compare their drop-out rates along a 2-year follow-up period. BPD was assessed using the Structured Clinical Interview for DSM-IV axis II personality disorders. All participants also completed the Positive And Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning (GAF) scale. Forty-nine (9.6%) FEP participants showed a BPD diagnosis. FEP individuals with BPD had a higher baseline prevalence of substance misuse, a lower baseline equivalent dose of antipsychotic medication, lower baseline levels of negative symptoms, and higher baseline levels of anxious-depressive features. They also had a higher 2-year drop-out rate. In conclusion, BPD is present in 10% of FEP patients. This FEP subgroup has peculiar clinical challenges (e.g. high substance misuse at entry, high drop-out rate) and additional comorbidities (e.g. high levels of depressive symptoms at entry), which would require appropriate treatment guidelines. [ABSTRACT FROM AUTHOR]