부산대학교 도서관

Abstract. The clinical impact of gallium-67 scintigraphy before and after therapy for lymphoma remains controversial. The aims of this study were: (1) to compare the staging of lymphoma by [sup 67]Ga scintigraphy only with staging by clinical examination and conventional imaging (CI), and (2) to analyse the clinical relevance of both [sup 67]Ga imaging and CI after treatment. From March 1995 to November 1998, 86 [sup 67]Ga scintigraphy studies were performed in 62 patients with Hodgkin's disease (n = 52) or non-Hodgkin's lymphoma (n = 10). [sup 67]Ga scintigraphy was performed at diagnosis (n = 44) or after therapy (n = 42) using 185-220 MBq [sup 67]Ga citrate and planar and single-photon emission tomography (SPET) studies. Treatment comprised radiotherapy, chemotherapy or combined modalities. CI included plain chest radiography, computed tomography (CT) of the chest and abdomen/pelvis, ultrasound of the abdomen, lymphography, bone marrow biopsy and, when necessary, magnetic resonance imaging (MRI) and bone scintigraphy. For individual suspected sites of disease before treatment, complete agreement between clinical examination and CI on the one hand and [sup 67]Ga scintigraphy on the other hand was observed in 25/44 patients (57%; 95% confidence interval 41%-72%). Clinical examination and CI showed more sites than did [sup 67]Ga scintigraphy in... [ABSTRACT FROM AUTHOR]