학술논문
Meropenem/vaborbactam plus aztreonam for the treatment of New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae infections.
Document Type
Article
Author
Source
Subject
*AZTREONAM
*KLEBSIELLA infections
*MEROPENEM
*KLEBSIELLA pneumoniae
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Language
ISSN
0305-7453
Abstract
Meropenem/vaborbactam plus aztreonam as a possible treatment strategy for bloodstream infections caused by ceftazidime/avibactam-resistant Klebsiella pneumoniae: a retrospective case series and literature review. Future studies are needed to compare the MER/VAB+ATM combination with CAZ/AVI+ATM in MBL-producing Kp infections. Metallo- -lactamase (MBL)-producing I Klebsiella pneumoniae i (Kp) is increasingly reported in Europe and the United States, and limited treatment options are available against this superbug.[[1], [3], [5]] MBLs hydrolyse all -lactams except aztreonam, but this latter cannot be used as monotherapy because of the co-production of expanded-spectrum- -lactamases (ESBL). [Extracted from the article]