학술논문
Integrating insulin secretion and ER stress in pancreatic ?-cells.
Document Type
Article
Author
Source
Subject
*INSULIN
*ENDOPLASMIC reticulum
*PANCREATIC physiology
*INGESTION
*B cells
*GLUCOSE in the body
*INCRETINS
*WOLFRAM syndrome
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Language
ISSN
1465-7392
Abstract
After food consumption, insulin-secreting pancreatic ?-cells detect increased glucose and incretin hormones, and respond by releasing insulin. Wolfram syndrome 1, a protein that mitigates endoplasmic reticulum (ER) stress, is now shown to regulate insulin synthesis and release - revealing a molecular point of convergence between the ER stress and insulin release pathways. [ABSTRACT FROM AUTHOR]