부산대학교 도서관

Background: Patients undergoing corneal abrasion as part of Descemet membrane endothelial keratoplasty (DMEK) under general anesthesia suffer from early burning pain postoperatively. This pain appears to be poorly treatable with systemic analgesics. This study aims to evaluate postoperative pain management using topical lidocaine gel after DMEK with iatrogenic corneal abrasion. Methods: Retrospective analysis of 28 consecutive patients undergoing DMEK with corneal abrasion from October 19, 2021, to November 12, 2021, at a German university hospital. Patients during week 1 and 2 received peri-operative standard pain treatment (cohort S) and additional local lidocaine gel during week 3 and 4 immediately postoperatively (cohort L). Results: 13 patients were included in cohort S and 15 patients in cohort L. At awakening all patients (100%) in cohort S reported burning pain, and six of 15 patients (40%) in cohort L reported burning pain. Burning pain scores were significantly lower in cohort L (p < 0.001 at awakening, p < 0.001 at 10 min, p < 0.001 at 20 min, p < 0.001 at 30 min, p = 0.007 at 40 min after awakening, and p < 0.001 at leaving recovery room). No significant differences between cohort S and cohort L were detected concerning surgical outcome during 1-month-follow-up (p = 0.901 for best corrected visual acuity). Conclusion: Patients undergoing DMEK with corneal abrasion suffer significant pain in the recovery room. A single dose of topic lidocaine gel reduces the early postoperative burning pain sufficiently and does not affect the surgical outcome. Key messages: What is already known on this topic: Descemet membrane endothelial keratoplasty (DMEK) normally causes low levels of pain. What this study adds: When corneal abrasion is required during DMEK surgery under general anesthesia, patients experience pain sensations that can severely affect their well-being. An immediate postoperative single dose of topical lidocaine gel applied by the surgeon reduces the early burning pain sufficiently and does not affect the surgical outcome. To reduce postoperative pain levels and to improve the postoperative well-being of patients, all patients undergoing DMEK with corneal abrasion should receive topical lidocaine gel at least once. However, this simple intervention should still be investigated in prospective studies. [ABSTRACT FROM AUTHOR]