학술논문
PHOTOCHEMICAL SYNTHESIS OF NOVEL DIDEOXYNUCLEOSIDES.
Document Type
Article
Author
Source
Subject
*BIOSYNTHESIS
*BIOCHEMISTRY
*NUCLEOSIDES
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*
Language
ISSN
1525-7770
Abstract
A series of 2′,3′-dideoxynucleosides based on the apiose family was prepared from photochemical ring-expansion of a common cyclobutanone precursor. The starting ketone, (±) 3-[2′-(benzoyloxy)ethyl]-2,2-dimethylcyclobutanone (12) was prepared from commercially available (±)α-pinene. Since the optically pure antipodes of α-pinene are also commercially available, these nucleosides can be prepared optically pure using the identical procedure. [ABSTRACT FROM AUTHOR]