학술논문
Neuron‐intrinsic origin of hyperexcitability during early pathogenesis of Alzheimer's disease: An Editorial Highlight for "Hippocampal hyperactivity in a rat model of Alzheimer's disease" on https://doi.org/10.1111/jnc.15323.
Document Type
Article
Source
Subject
*AMYLOID plaque
*ALZHEIMER'S disease
*ANIMAL disease models
*PATHOGENESIS
*HIPPOCAMPUS (Brain)
*LABORATORY mice
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Language
ISSN
0022-3042
Abstract
In Alzheimer's disease (AD), hippocampal hyperactivation is already present at early stages of the disorder, in some cases, even when the individual is still asymptomatic. Neuronal hyperexcitability has been described to occur before the deposition of amyloid beta plaques in mouse models of AD and has been attributed to an imbalance between excitatory and inhibitory activity. In this Editorial Highlight, we discuss the article by Sosulina et al., published in this issue of the Journal of Neurochemistry, which offers novel insights into the possible origins of this neuronal excitability observed during the early pathogenesis of AD. [ABSTRACT FROM AUTHOR]