학술논문
Macrolide-Resistant Shigella sonnei.
Document Type
Article
Author
Source
Subject
*SHIGELLA sonnei
*MACROLIDE antibiotics
*AZITHROMYCIN
*ANTIBIOTICS
*MACROCYCLIC compounds
*BACTERIAL diseases
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Language
ISSN
1080-6040
Abstract
Shigella sonnei UCN59, isolated during an outbreak of S. sonnei in January 2007, was resistant to azithromycin (MIC 64 mg/L). The isolate contained a plasmid-borne mph(A) gene encoding a macrolide 2'-phosphotransferase that inactivates macrolides. Emergence of the mph(A) gene in S. sonnei may limit usefulness of azithromycin for treatment of shigellosis. [ABSTRACT FROM AUTHOR]