학술논문
Radiologically isolated syndrome in the spectrum of multiple sclerosis.
Document Type
Article
Source
Subject
*MULTIPLE sclerosis
*DISEASE risk factors
*SYNDROMES
*
*
Language
ISSN
1352-4585
Abstract
The radiologically isolated syndrome (RIS) currently represents the earliest detectable preclinical phase of multiple sclerosis (MS). Remarkable advancements have been recently made, including the identification of risk factors for disease evolution, revisions to the existing 2009 RIS criteria, and our understanding of the impact of early disease-modifying therapy use in the prevention/delay of symptomatic MS from two randomized clinical trials. Here, we discuss RIS in the context of the spectrum of MS, implications in the clinical management of individuals, and provide insights into future opportunities and challenges given the anticipated inclusion of asymptomatic MS in the formal definition of MS. [ABSTRACT FROM AUTHOR]