학술논문
Maturation by LctT Is Required for Biosynthesis of Full-Length Lantibiotic Lacticin 481.
Document Type
Article
Author
Source
Subject
*BIOSYNTHESIS
*PEPTIDES
*SCISSION (Chemistry)
*MASS spectrometry
*MICROBIAL ecology
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Language
ISSN
0099-2240
Abstract
In lantibiotic lacticin 481 biosynthesis, LctT cleaves the precursor peptide and exports mature lantibiotic. Matrix-assisted laser desorption ionization-time of flight mass spectrometry revealed that a truncated form of iacticin 481 is produced in the absence of LctT or after cleavage site inactivation. Production of truncated lacticin 481 is 4-fold less efficient, and its specific activity is about 10-fold lower. [ABSTRACT FROM AUTHOR]