학술논문
Structural Insertion/Deletion Variation in IRF5 Is Associated With a Risk Haplotype and Defines the Precise IRF5 Isoforms Expressed in Systemic Lupus Erythematosus.
Document Type
Article
Author
Source
Subject
*INTERFERONS
*SYSTEMIC lupus erythematosus
*AUTOIMMUNE diseases
*NUCLEOTIDES
*GENETIC polymorphisms
*INFLAMMATION
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Language
ISSN
0004-3591
Abstract
This article discusses findings of a study, which determined whether specific isoforms of IRF5 are transcribed in patients with systemic lupus erythematosus who have risk genotypes in the exon 1B donor splice site at single-nucleotide polymorphism. A key component of the type I interferon pathway, IRF5 has a genetic association with systemic lupus erythematosus (SLE) and is involved in the transcriptional activation of various proinflammatory cytokines and interferon-α.