학술논문
Comparing weight‐based dosing of tacrolimus XR in obese and non‐obese renal transplant recipients.
Document Type
Article
Author
Source
Subject
*KIDNEY transplantation
*TACROLIMUS
*OBESITY
*BODY weight
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Language
ISSN
0902-0063
Abstract
The recommended initial weight‐based dose of extended‐release (XR) tacrolimus (Envarsus XR) in kidney transplant recipients (KTR) is 0.14 mg/kg/day. However, no data exist regarding dosing recommendations for obese patients specifically. The aim of this study was to evaluate weight‐based dosing requirements in a cohort of obese KTR who were initiated on de novo tacrolimus XR post‐transplantation. The primary outcome was weight‐based dosing requirements (mg/kg/day) on post‐operative day (POD) 7 and 14. Of the 254 KTR, 81 (31%) were obese. The median therapeutic dose on POD7 was 0.1 versus 0.12 vs. 0.14 mg/kg/day in the BMI > 30 kg/m2, BMI 25–30 kg/m2, and BMI < 25 kg/m2, respectively, (p =.0001). This result was similar on POD14; median therapeutic dose was 0.09 versus 0.11 versus 0.15 mg/kg/day in the BMI > 30 kg/m2, BMI 25–30 kg/m2, and BMI < 25 kg/m2, respectively, (p <.001). Therapeutic dose on POD7 and POD14 based on ideal body was similar in all cohorts (p =.238, p =.923, respectively). This finding was supported by a strong linear relationship between ideal body weight (IBW) and therapeutic dose (r =.929). In both obese and non‐obese KTR, IBW had a stronger correlation with the therapeutic dose for tacrolimus XR. [ABSTRACT FROM AUTHOR]