학술논문
Search and Contain: Impact of an Integrated Genomic and Epidemiological Surveillance and Response Program for Control of Carbapenemase-producing Enterobacterales.
Document Type
Article
Author
Lane, Courtney R; Brett, Judith; Schultz, Mark; Gorrie, Claire L; Stevens, Kerrie; Cameron, Donna R M; George, Siobhan St; Diemen, Annaliese van; Easton, Marion; Stuart, Rhonda L; Sait, Michelle; Peleg, Anton Y; Stewardson, Andrew J; Cheng, Allen C; Spelman, Denis W; Waters, Mary Jo; Ballard, Susan A; Sherry, Norelle L; Williamson, Deborah A; Romanes, Finn
Source
Subject
*PUBLIC health surveillance
*CLUSTER sampling
*EVALUATION of human services programs
*SINGLE nucleotide polymorphisms
*ENTEROBACTERIACEAE diseases
*GENETIC testing
*PUBLIC health
*COMPARATIVE studies
*GENOMICS
*INFECTIOUS disease transmission
*COMMUNITY-acquired infections
*DESCRIPTIVE statistics
*LONGITUDINAL method
*DISEASE risk factors
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Language
ISSN
1058-4838
Abstract
Background Multiresistant organisms (MROs) pose a critical threat to public health. Population-based programs for control of MROs such as carbapenemase-producing Enterobacterales (CPE) have emerged and evaluation is needed. We assessed the feasibility and impact of a statewide CPE surveillance and response program deployed across Victoria, Australia (population 6.5 million). Methods A prospective multimodal intervention including active screening, carrier isolation, centralized case investigation, and comparative pathogen genomics was implemented. We analyzed trends in CPE incidence and clinical presentation, risk factors, and local transmission over the program's first 3 years (2016–2018). Results CPE case ascertainment increased over the study period to 1.42 cases/100 000 population, linked to increased screening without a concomitant rise in active clinical infections (0.45–0.60 infections/100 000 population, P = .640). KPC-2 infection decreased from 0.29 infections/100 000 population prior to intervention to 0.03 infections/100 000 population in 2018 (P = .003). Comprehensive case investigation identified instances of overseas community acquisition. Median time between isolate referral and genomic and epidemiological assessment for local transmission was 11 days (IQR, 9–14). Prospective surveillance identified numerous small transmission networks (median, 2; range, 1–19 cases), predominantly IMP and KPC, with median pairwise distance of 8 (IQR, 4–13) single nucleotide polymorphisms; low diversity between clusters of the same sequence type suggested genomic cluster definitions alone are insufficient for targeted response. Conclusions We demonstrate the value of centralized CPE control programs to increase case ascertainment, resolve risk factors, and identify local transmission through prospective genomic and epidemiological surveillance; methodologies are transferable to low-prevalence settings and MROs globally. [ABSTRACT FROM AUTHOR]