학술논문

PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review.
Document Type
Article
Source
International Journal of Molecular Sciences. Sep2022, Vol. 23 Issue 17, p10025. 14p.
Subject
*PHOSPHOPROTEIN phosphatases
*IMMUNITY
*IMMUNOTHERAPY
*CELL migration
*CELL differentiation
*T cells
*PROTEIN-tyrosine phosphatase
Language
ISSN
1661-6596
Abstract
PTPN2 (protein tyrosine phosphatase non-receptor 2), also called TCPTP (T cell protein tyrosine phosphatase), is a member of the PTP family signaling proteins. Phosphotyrosine-based signaling of this non-transmembrane protein is essential for regulating cell growth, development, differentiation, survival, and migration. In particular, PTPN2 received researchers' attention when Manguso et al. identified PTPN2 as a cancer immunotherapy target using in vivo CRISPR library screening. In this review, we attempt to summarize the important functions of PTPN2 in terms of its structural and functional properties, inflammatory reactions, immunomodulatory properties, and tumor immunity. PTPN2 exerts synergistic anti-inflammatory effects in various inflammatory cells and regulates the developmental differentiation of immune cells. The diversity of PTPN2 effects in different types of tumors makes it a potential target for tumor immunotherapy. [ABSTRACT FROM AUTHOR]