학술논문
Differential adhesion drives angiogenesis.
Document Type
Article
Author
Source
Subject
*BLOOD vessel prosthesis
*NEOVASCULARIZATION
*ADHESION
*TISSUE analysis
*ORGANS (Anatomy)
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Language
ISSN
1465-7392
Abstract
New blood vessels sprout from existing vasculature to ensure vascularization of developing organs and tissues. A combination of computational modelling and experimental analysis shows that sprout elongation is mediated by differential adhesion dynamics among endothelial cells. The adhesiveness of an individual endothelial cell is governed by VEGF and Notch signalling. [ABSTRACT FROM AUTHOR]