학술논문
A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation.
Document Type
Article
Author
Source
Subject
*ADP-ribosylation
*ADP-ribosyltransferases
*POLYMERASES
*MOLECULES
*PROTEINS
*POLY ADP ribose
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*
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Language
ISSN
1359-7345
Abstract
An NAD+ featuring an adenosyl 4′-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule represents the first ribose-functionalized NAD+ with versatile activities across different ADP-ribosyltransferases and provides insight into developing new probes for ADP-ribosylation. [ABSTRACT FROM AUTHOR]