학술논문
Early caffeine therapy and clinical outcomes in extremely preterm infants.
Document Type
Article
Author
Source
Subject
*BRONCHOPULMONARY dysplasia prevention
*CAFFEINE
*ARTIFICIAL respiration
*CHI-squared test
*FISHER exact test
*PREMATURE infants
*LONGITUDINAL method
*NEONATAL intensive care
*HEALTH outcome assessment
*PATENT ductus arteriosus
*T-test (Statistics)
*LOGISTIC regression analysis
*NEONATAL intensive care units
*TREATMENT effectiveness
*RETROSPECTIVE studies
*DATA analysis software
*DESCRIPTIVE statistics
*THERAPEUTICS
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Language
ISSN
0743-8346
Abstract
Objective:To determine if early caffeine (EC) therapy is associated with decreased bronchopulmonary dysplasia (BPD) or death, decreased treatment of patent ductus arteriosus (PDA), or shortened duration of ventilation.Study Design:In a retrospective cohort of 140 neonates 1250 g at birth, infants receiving EC (initiation <3 days of life) were compared with those receiving late caffeine (LC, initiation 3 days of life) using logistic regression.Result:Of infants receiving EC, 25% (21/83) died or developed BPD compared with 53% (30/57) of infants receiving LC (adjusted odds ratio (aOR) 0.26, 95% confidence interval (CI) 0.09 to 0.70; P<0.01). PDA required treatment in 10% of EC infants versus 36% of LC infants (aOR 0.28, 95%CI 0.10 to 0.73; P=0.01). Duration of mechanical ventilation was shorter in infants receiving EC (EC, 6 days; LC, 22 days; P<0.01).Conclusion:Infants receiving EC therapy had improved neonatal outcomes. Further studies are needed to determine if caffeine prophylaxis should be recommended for preterm infants. [ABSTRACT FROM AUTHOR]