학술논문
Synthesis of pyrido[3,4- d]pyrimidines by condensation of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate with morpholine-4-carboxamidine.
Document Type
Article
Author
Source
Subject
*PYRIMIDINES
*PIPERIDINE
*AMIDINES
*HETEROCYCLIC compounds
*HETEROCYCLIC chemistry
*ORGANIC chemistry
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Language
ISSN
0009-3122
Abstract
A method has been developed for the synthesis of 4-amino-substituted 7-benzyl-2-morpholin-4-yl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidines by condensation of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate with morpholine-4-carboxamidine and subsequent reaction of the 7-benzyl-2-morpholin-4-yl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one with trifluoromethanesulfonic anhydride and secondary amines. [ABSTRACT FROM AUTHOR]