학술논문
Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia.
Document Type
Article
Author
Source
Subject
*MYELOID leukemia
*MYELOPROLIFERATIVE neoplasms
*MYELODYSPLASTIC syndromes
*GENES
*CANCER chemotherapy
*HEMATOPOIETIC stem cell transplantation
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Language
ISSN
0887-6924
Abstract
The article discusses the study on myeloid progenitors with PTPN11 gene and nonRAS pathway gene mutations for treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia, a fatal mixed myeloproliferative and myelodysplastic disorder. The study involves seven cases of patients with chromosomal changes after chemotherapy or allogeneic hematopoietic stem cell transplantation. It notes that the study first examines the presence of JAK3 and SETBP1 gene mutations in 29 patients.