학술논문
Daikenchuto increases blood flow in the superior mesenteric artery in humans: A comparison study between four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction magnetic resonance imaging and Doppler ultrasound.
Document Type
Article
Author
Suzuki, Katsunori; Takehara, Yasuo; Sakata, Mayu; Kawate, Masanori; Ohishi, Naoki; Sugiyama, Kosuke; Akai, Toshiya; Suzuki, Yuhi; Sugiyama, Masataka; Kawamura, Takafumi; Morita, Yoshifumi; Kikuchi, Hirotoshi; Hiramatsu, Yoshihiro; Yamamoto, Masayoshi; Nasu, Hatsuko; Johnson, Kevin; Wieben, Oliver; Kurachi, Kiyotaka; Takeuchi, Hiroya
Source
Subject
*DOPPLER ultrasonography
*FOUR-dimensional imaging
*MAGNETIC resonance imaging
*MESENTERIC artery
*BLOOD flow
*ULTRASONIC imaging
*HUMAN experimentation
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Language
ISSN
1932-6203
Abstract
Respiratory-gated four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction (4D PC-VIPR) is magnetic resonance (MR) imaging technique that enables analysis of vascular morphology and hemodynamics in a single examination using cardiac phase resolved 3D phase-contrast magnetic resonance imaging. The present study aimed to assess the usefulness of 4D PC-VIPR for the superior mesenteric artery (SMA) flowmetry before and after flow increase was induced by the herbal medicine Daikenchuto (TJ-100) by comparing it with Doppler ultrasound (DUS) as a current standard. Twenty healthy volunteers were enrolled in this prospective single-arm study. The peak cross-sectionally averaged velocity was measured by 4D PC-VIPR, peak velocity was measured by DUS, and flow volume (FV) of SMA and aorta were measured by 4D PC-VIPR and DUS 25 min before and after the peroral administration of TJ-100. The peak cross-sectionally averaged velocity, peak velocity, and FV of SMA measured by 4D PC-VIPR and DUS significantly increased after administration of TJ-100 (4D PC-VIPR: the peak cross-sectionally averaged velocity; p = 0.004, FV; p = 0.035, DUS: the peak velocity; p = 0.003, FV; p = 0.010). Furthermore, 4D PC-VIPR can analyze multiple blood vessels simultaneously. The ratio of the SMA FV to the aorta, before and after oral administration on the 4D PC-VIPR test also increased (p = 0.015). The rate of change assessed by 4D PC-VIPR and DUS were significantly correlated (the peak cross-sectionally averaged velocity and peak velocity: r = 0.650; p = 0.005, FV: r = 0.659; p = 0.004). Retrospective 4D PC-VIPR was a useful modality for morphological and hemodynamic analysis of SMA. [ABSTRACT FROM AUTHOR]