학술논문
Epidemiology of haemophagocytic lymphohistiocytosis at the population level in Germany.
Document Type
Article
Author
Source
Subject
*HEMOPHAGOCYTIC lymphohistiocytosis
*EPIDEMIOLOGY
*OLDER patients
*MACROPHAGE activation syndrome
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Language
ISSN
0007-1048
Abstract
Summary: We retrospectively analysed all German inpatient cases of haemophagocytic lymphohistiocytosis (HLH) from 2014 to 2020 to describe the epidemiology, clinical course, and underlying diseases of 4065 HLH patients. The age‐standardized incidence rate of HLH in Germany was 0.52/100 000 people in 2014 and steadily increased by 10% per year to 0.97/100 000 in 2020 (mean 0.70/100 000). Inpatient deaths related to HLH increased from 0.84/1 000 000 people in 2014 to 2.32/1 000 000 people in 2020, caused by rising numbers of older HLH patients. Overall, HLH is more frequent than previously expected and incidence as well as HLH‐related deaths increased significantly. [ABSTRACT FROM AUTHOR]