학술논문
Compensatory gene expression potentially rescues impaired brain development in Kit mutant mice.
Document Type
Article
Source
Subject
*GENE expression
*NEURAL development
*RIBOSOMAL proteins
*OXIDATIVE phosphorylation
*TISSUE arrays
*
*
*
*
Language
ISSN
2045-2322
Abstract
While loss-of-function mutations in the murine dominant white spotting/Kit (W) locus affect a diverse array of cell lineages and organs, the brain, organ with the highest expression show the least number of defective phenotypes. We performed transcriptome analysis of the brains of KitW embryos and found prominent gene expression changes specifically in the E12.5 KitW/W homozygous mutant. Although other potentially effective changes in gene expression were observed, uniform downregulation of ribosomal protein genes and oxidative phosphorylation pathway genes specifically observed in the E12.5 brain may comprise a genetic compensation system exerting protective metabolic effects against the deleterious effect of KitW/W mutation in the developing brain. [ABSTRACT FROM AUTHOR]