학술논문
Quantitative Determination of Mycophenolic Acid in Human Blood Plasma by High-Performance Liquid Chromatography with Tandem Mass-Spectrometric Detection.
Document Type
Article
Author
Source
Subject
*MYCOPHENOLIC acid
*BLOOD plasma
*HIGH performance liquid chromatography
*DRUG use testing
*PHARMACOKINETICS
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Language
ISSN
0091-150X
Abstract
A new rapid and accurate method for determining the mycophenolic acid concentration in human blood plasma using HPLC with tandem mass-spectrometric detection (HPLC-MS/MS) and deproteinization for sample preparation was developed. The method was validated according to the Guideline for Validation of Bioanalytical Methods of EMEA and Guidelines for Examination of Drugs. This method was used to study the pharmacokinetics of mycophenolate sodium. [ABSTRACT FROM AUTHOR]