학술논문
Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study.
Document Type
Article
Author
Pham, Thu-Thi; Nimptsch, Katharina; Aleksandrova, Krasimira; Jenab, Mazda; Reichmann, Robin; Wu, Kana; Tjønneland, Anne; Kyrø, Cecilie; Schulze, Matthias B.; Kaaks, Rudolf; Katzke, Verena; Palli, Domenico; Pasanisi, Fabrizio; Ricceri, Fulvio; Tumino, Rosario; Krogh, Vittorio; Roodhart, Jeanine; Castilla, Jesús; Sánchez, Maria-Jose; Colorado-Yohar, Sandra Milena
Source
Subject
*LIFESTYLES
*ADIPOKINES
*C-reactive protein
*CONFIDENCE intervals
*INFLAMMATION
*CASE-control method
*RESISTIN
*COLORECTAL cancer
*WAIST circumference
*TUMOR markers
*LOGISTIC regression analysis
*BODY mass index
*HIGH density lipoproteins
*EDUCATIONAL attainment
*C-peptide
*DISEASE risk factors
*BLOOD
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Language
ISSN
2072-6694
Abstract
Simple Summary: Resistin has been proposed to link to cancer development via inflammatory processes. Prior case-control studies suggest higher post-diagnosis resistin concentrations in CRC cases compared to controls. Here, we found no association between pre-diagnostic circulating resistin concentrations and the risk of CRC; however, we observed a marginally significant association among cases (and their matched controls) diagnosed with CRC within the first two years of follow-up, whereas no such association was observed among cases (and their matched controls) diagnosed with CRC after two years of follow-up. We speculate that resistin is more likely a marker of existing tumors than a risk factor of CRC. Resistin is a polypeptide implicated in inflammatory processes, and as such could be linked to colorectal carcinogenesis. In case-control studies, higher resistin levels have been found in colorectal cancer (CRC) patients compared to healthy individuals. However, evidence for the association between pre-diagnostic resistin and CRC risk is scarce. We investigated pre-diagnostic resistin concentrations and CRC risk within the European Prospective Investigation into Cancer and Nutrition using a nested case-control study among 1293 incident CRC-diagnosed cases and 1293 incidence density-matched controls. Conditional logistic regression models controlled for matching factors (age, sex, study center, fasting status, and women-related factors in women) and potential confounders (education, dietary and lifestyle factors, body mass index (BMI), BMI-adjusted waist circumference residuals) were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for CRC. Higher circulating resistin concentrations were not associated with CRC (RR per doubling resistin, 1.11; 95% CI 0.94–1.30; p = 0.22). There were also no associations with CRC subgroups defined by tumor subsite or sex. However, resistin was marginally associated with a higher CRC risk among participants followed-up maximally two years, but not among those followed-up after more than two years. We observed no substantial correlation between baseline circulating resistin concentrations and adiposity measures (BMI, waist circumference), adipokines (adiponectin, leptin), or metabolic and inflammatory biomarkers (C-reactive protein, C-peptide, high-density lipoprotein cholesterol, reactive oxygen metabolites) among controls. In this large-scale prospective cohort, there was little evidence of an association between baseline circulating resistin concentrations and CRC risk in European men and women. [ABSTRACT FROM AUTHOR]