학술논문
Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient.
Document Type
Article
Author
Source
Subject
*GANCICLOVIR
*CYTOMEGALOVIRUS diseases
*BONE marrow transplantation
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*
Language
ISSN
1398-2273
Abstract
A 20-year-old patient, who received a bone marrow transplant in order to treat metachromatic leukodystrophy (MLD), succumbed to cytomegalovirus (CMV) encephalitis. After CMV viremia developed, the patient received ganciclovir, but he was switched to foscarnet when ganciclovir resistance was suspected. Foscarnet was discontinued because of concern about its potential central nervous system toxicity. Autopsy samples of brain and cerebrospinal fluid contained CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. No foscarnet resistance mutations were found. [ABSTRACT FROM AUTHOR]