학술논문
Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes.
Document Type
Journal Article
Author
Wawina-Bokalanga, Tony; Vanmechelen, Bert; Lhermitte, Valentine; Martí-Carreras, Joan; Vergote, Valentijn; Koundouno, Fara Raymond; Akoi-Boré, Joseph; Thom, Ruth; Tipton, Tom; Steeds, Kimberley; Moussa, Kéita Balla; Amento, Ablam; Laenen, Lies; Duraffour, Sophie; Gabriel, Martin; Ruibal, Paula; Hall, Yper; Kader-Kondé, Mandy; Günther, Stephan; Baele, Guy
Source
Subject
*RESEARCH
*EBOLA virus disease
*HLA-B27 antigen
*RESEARCH methodology
*CELL receptors
*ALLELES
*MEDICAL cooperation
*EVALUATION research
*COMPARATIVE studies
*GENOTYPES
*PROBABILITY theory
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Language
ISSN
1080-6040
Abstract
We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). We genotyped KIRs and HLA class I alleles using DNA from uninfected controls, EVD survivors, and persons who died of EVD. The activating 2DS4-003 and inhibitory 2DL5 genes were significantly more common among persons who died of EVD; 2DL2 was more common among survivors. We used logistic regression analysis and Bayesian modeling to identify 2DL2, 2DL5, 2DS4-003, HLA-B-Bw4-Thr, and HLA-B-Bw4-Ile as probably having a significant relationship with disease outcome. Our findings highlight the importance of innate immune response against Ebola virus and show the association between KIRs and the clinical outcome of EVD. [ABSTRACT FROM AUTHOR]