학술논문
Fading SARS-CoV-2 humoral VOC cross-reactivity and sustained cellular immunity in convalescent children and adolescents.
Document Type
Article
Author
Paniskaki, Krystallenia; Goretzki, Sarah; Anft, Moritz; Konik, Margarethe J.; Lechtenberg, Klara; Vogl, Melanie; Meister, Toni L.; Pfaender, Stephanie; Zettler, Markus; Jäger, Jasmin; Dolff, Sebastian; Westhoff, Timm H.; Rohn, Hana; Felderhoff-Mueser, Ursula; Stervbo, Ulrik; Witzke, Oliver; Dohna-schwake, Christian; Babel, Nina
Source
Subject
*CELLULAR immunity
*SARS-CoV-2
*SARS-CoV-2 Omicron variant
*HUMORAL immunity
*CROSS reactions (Immunology)
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Language
ISSN
1471-2334
Abstract
Cross-reactive cellular and humoral immunity can substantially contribute to antiviral defense against SARS-CoV-2 variants of concern (VOC). While the adult SARS-CoV-2 cellular and humoral immunity and its cross-recognition potential against VOC is broadly analyzed, similar data regarding the pediatric population are missing. In this study, we perform an analysis of the humoral and cellular SARS-CoV-2 response immune of 32 convalescent COVID-19 children (children), 27 convalescent vaccinated adults(C + V+) and 7 unvaccinated convalescent adults (C + V-). Similarly to adults, a significant reduction of cross-reactive neutralizing capacity against delta and omicron VOC was observed 6 months after SARS-CoV-2 infection. While SAR-CoV-2 neutralizing capacity was comparable among children and C + V- against all VOC, children demonstrated as expected an inferior humoral response when compared to C + V+. Nevertheless, children generated SARS-CoV-2 reactive T cells with broad cross-recognition potential. When compared to V + C+, children presented even comparable frequencies of WT-reactive CD4 + and CD8 + T cells with high avidity and functionality. Taking into consideration the limitations of study - unknown disease onset for 53% of the asymptomatic pediatric subjects, serological detection of SARS-CoV-2 infection-, our results suggest that following SARS-CoV-2 infection children generate a humoral SARS-CoV-2 response with neutralizing potential comparable to unvaccinated COVID-19 convalescent adults as well a sustained SARS-CoV-2 cellular response cross-reactive to VOC. Key statement: Following SARS-CoV-2 infection children generate a humoral SARS-CoV-2 response with neutralizing potential comparable to unvaccinated COVID-19 convalescent adults as well a sustained robust SARS-CoV-2 cellular response cross-reactive to VOC, comparable to vaccinated convalescent adults with respect to magnitude and functionality. [ABSTRACT FROM AUTHOR]