부산대학교 도서관

Aim: To verify the utility of the 2‐in‐1‐out‐compartment model analysis (CMA) of intravenous contrast‐enhanced dynamic computed tomography (IV‐CT) for evaluating hepatic arterial and portal venous flow using intra‐arterial contrast‐enhanced CT (IA‐CT). Methods: We retrospectively evaluated 49 consecutive patients who underwent IV‐CT and were radiologically or histologically diagnosed as having hepatic malignant lesion (51 classical hepatocellular carcinomas [HCC], 4 early HCC, 3 cholangiolocellular carcinomas, 1 mixed HCC, 3 cholangiocellular carcinomas). As a gold standard for hepatic arterial and portal blood flows, we defined the normalized enhancement in CT values on CTAP (nCTAP) and CTHA (nCTHA). The hepatic arterial (k1a) and portal venous inflow velocity (k1p) constants in hepatic lesions and surrounding liver parenchyma were obtained from the CMA of IV‐CT with various outflow velocity constant (k2) limits using the nonlinear least square method. The correlation coefficient between the normalized enhancement in IA‐CT and CMA of IV‐CT was statistically evaluated according to various k2 limits. Results: The highest mean correlation coefficient between k1a and nCTHA (r = 0.65, P < 0.0001) was observed when k2 ≦0.035. The highest mean correlation coefficient between k1p and nCTAP (r = 0.69, P < 0.0001) was observed when k2≦0.045. The decrease in correlation coefficient was significant when the upper k2 limit was lower than 0.03 or higher than 0.07 compared to the best mean correlation coefficient (P < 0.05). Conclusion: Hepatic arterial and portal venous flows can be evaluated quantitatively to some extent with appropriate outflow velocity constant limits using the CMA of IV‐CT. [ABSTRACT FROM AUTHOR]