부산대학교 도서관

Objective:Fish oil (FO) may attenuate the inflammatory response after major surgery such as abdominal aortic aneurysm (AAA) surgery. We aimed at evaluating the clinical impact and safety aspects of a FO containing parenteral nutrition (PN) after AAA surgery.Methods:Intervention consisted in 4 days of either standard (STD: Lipofundin medium-chain triglyceride (MCT): long-chain triglyceride (LCT)50%–MCT50%) or FO containing PN (FO: Lipoplus: LCT40%–MCT50%–FO10%). Energy target were set at 1.3 times the preoperative resting energy expenditure by indirect calorimetry. Blood sampling on days 0, 2, 3 and 4. Glucose turnover by the 2H2-glucose method. Muscle microdialysis. Clinical data: maximal daily T°, intensive care unit (ICU) and hospital stay.Results:Both solutions were clinically well tolerated, without any differences in laboratory safety parameters, inflammatory, metabolic data, or in organ failures. Plasma tocopherol increased similarly; with FO, docosahexaenoic and eicosapentaenoic acid increased significantly by day 4 versus baseline or STD. To increased postoperatively, with a trend to lower values in FO group (P=0.09). After FO, a trend toward shorter ICU stay (1.6±0.4 versus 2.3±0.4), and hospital stay (9.9±2.4 versus 11.3±2.7 days: P=0.19) was observed.Conclusions:Both lipid emulsions were well tolerated. FO-PN enhanced the plasma n–3 polyunsaturated fatty acid content, and was associated with trends to lower body temperature and shorter length of stay.European Journal of Clinical Nutrition (2008) 62, 1116–1122; doi:10.1038/sj.ejcn.1602817; published online 30 May 2007 [ABSTRACT FROM AUTHOR]