학술논문
Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons.
Document Type
Article
Author
Source
Subject
*THERAPEUTICS
*BIPOLAR disorder
*GENETICS of bipolar disorder
*GENOTYPES
*SINGLE nucleotide polymorphisms
*GENOMES
*GENETIC databases
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Language
ISSN
1932-6203
Abstract
The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome. [ABSTRACT FROM AUTHOR]