학술논문
2‐Pyridone Formation: An Efficient Method for the Solid‐Phase Synthesis of Homodimers.
Document Type
Article
Author
Source
Subject
*SOLID-phase synthesis
*HOMODIMERS
*PEPTIDES
*MOLECULES
*LIGANDS (Chemistry)
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Language
ISSN
0947-6539
Abstract
This study presents an efficient method for on‐resin dimer generation through self‐condensation of 3,3‐dimethoxypropionic acid‐modified molecules, resulting in 2‐pyridones. The approach demonstrated remarkable versatility by producing homodimers of peptides, peptoids, and non‐peptidic ligands. Its ease of application, broad utility, and mild reaction conditions not only hold significance for peptide and peptoid research but also offer potential for the on‐resin development of a wide range of bivalent ligands. [ABSTRACT FROM AUTHOR]