학술논문
Hemophagocytic Lymphohistiocytosis Related to Tuberculosis Disease.
Document Type
Article
Author
Source
Subject
*DIAGNOSIS of fever
*TUBERCULOSIS complications
*ANTITUBERCULAR agents
*DIFFERENTIAL diagnosis
*IMMUNOTHERAPY
*GENETIC mutation
*PLASMA exchange (Therapeutics)
*TREATMENT effectiveness
*SEQUENCE analysis
*NON-langerhans-cell histiocytosis
*CHILDREN
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Language
ISSN
0972-5229
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a rare, albeit potentially fatal, condition in which fever, hepatosplenomegaly, and cytopenia predominate the clinical picture. Although it may be primary, it may also develop secondary to various etiologies. Herein, we aimed to report a patient who was diagnosed with pulmonary tuberculosis, developed fever and cytopenia during follow-up, and received immunomodulatory therapy together with antituberculosis therapy for the diagnosis of HLH. Sequencing of PRF1 showed heterozygous mutation. Although primary HLH has been detected in infants and children, genetic mutation of genes should be considered a differential diagnosis of HLH even in the adolescent. [ABSTRACT FROM AUTHOR]