학술논문
Proliferation control in neural stem and progenitor cells.
Document Type
Journal Article
Source
Subject
*CELL proliferation
*NEURAL stem cells
*PROGENITOR cells
*ETIOLOGY of diseases
*CELL growth
*BRAIN physiology
*CEREBRAL cortex
*STEM cells
*ANIMALS
*CELL physiology
*CELLS
*INSECTS
*MICE
*CRANIOFACIAL abnormalities
*PHYSIOLOGY
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Language
ISSN
1471-003X
Abstract
Neural circuit function can be drastically affected by variations in the number of cells that are produced during development or by a reduction in adult cell number owing to disease. For this reason, unique cell cycle and cell growth control mechanisms operate in the developing and adult brain. In Drosophila melanogaster and in mammalian neural stem and progenitor cells, these mechanisms are intricately coordinated with the developmental age and the nutritional, metabolic and hormonal state of the animal. Defects in neural stem cell proliferation that result in the generation of incorrect cell numbers or defects in neural stem cell differentiation can cause microcephaly or megalencephaly. [ABSTRACT FROM AUTHOR]