학술논문
A stable immature lattice packages IP6 for HIV capsid maturation.
Document Type
Article
Author
Source
Subject
*DNA primers
*GLYCOSAMINOGLYCANS
*REVERSE transcriptase
*
*
Language
ISSN
2375-2548
Abstract
The article presents a study which showed that HIV is evolutionarily constrained to maintain an immature lattice stability that ensures IP6 packaging without preventing maturation. Topics discussed include interdependence of IP6 binding and immature lattice stability, effects of treatment with the MI PF96, and IP6 incorporation as the key feature linking immature lattice stability to virion maturation and infectivity.