학술논문
Monoclonal Antibodies to PRAME Protein Slow the Development of PRAME-Expressing Tumor.
Document Type
Article
Author
Source
Subject
*TUMOR growth
*PROTEINS
*TUMORS
*MONOCLONAL antibodies
*MELANOMA
*TESTICULAR cancer
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Language
ISSN
1607-6729
Abstract
Two monoclonal antibodies recognizing non-overlapping epitopes of the PRAME protein were injected into immunocompetent mice to study their influence on the growth of subcutaneous tumor nodes. The B16F10 murine melanoma line, either expressing human PRAME protein or bearing only a vector without PRAME gene, were used as transplants. Each of the antibodies showed the ability to suppress tumor growth of a PRAME-expressing tumour, but not a tumor without PRAME. [ABSTRACT FROM AUTHOR]