부산대학교 도서관

Objective: In search of the neurobiology of obsessive-compulsive disorder (OCD), a number of studies investigated structural changes in the brain; however, there is no consensus on the results. While some of the studies present cortical thinning along with OCD, others report no thickness changes. Additionally, as only a limited number of studies focused on structural changes in adolescents with OCD, we aimed to study cortical thickness changes in adolescent OCD cases. Methods: 15 adolescents diagnosed with first-episode OCD using DSAI-V criteria and 15 age, sex and education matched healthy controls were included. Their T1 weighted magnetic resonance images (160 axial slices, gap=0, FOW=250 mm, voxel size=l mm isotropic, TR/TE/FIip=7700 ms/3800 ms/8°) taken with 3T MRI scanner were used under the local ethical committee approval (2020-102156). Data analysis is performed with CAT12 (http://www.neuro.uni-jena.de/cat/) software, and cortical thickness values were obtained for each cortical parcel of the DKT40 (Desikan-Killiany-Tounfille) atlas (https://surfer.nmr.mgh.harvard.edu/fsvfiki/CorticalParceIIation). Group comparisons with t-tests resulting in p<0.01 were reported. Results: Significant differences were found in 15 anatomical regions between OCD and control groups. Paracentral, post-central, precuneus, superior parietal gyri displayed bilateral thickening in adolescent OCD group compared with the healthy adolescents. Additionally, unilateral increases in cortical thickness were observed in right precentral, right inferior parietal, left pars orbitalis, left superior frontal, left caudal middle frontal, and left supramarginal gyri. Conclusion: The overlap between areas with increased thickness in adolescent OCD in the present study and those with reduced thickness reported in adult OCD studies in the literature provides an interesting perspective on the neurodevelop-mental aspect of the disorder. Furthermore, cortical thickness differences we observed in posterior areas such as precuneus, cuneus, right inferior parietal cortex in addition to areas of motor and executive functions, support recent OCD studies that claim the role of posterior association areas in the pathogenesis of the disease. [ABSTRACT FROM AUTHOR]