부산대학교 도서관

Aim There were differences in progression and prognosis of hepatocellular carcinoma ( HCC) after surgery between liver resection ( LR) and liver transplantation ( LT). In this study, immunohistochemical ( IHC) markers associated with the prognosis of HCC were assessed. Methods Data were collected from 167 patients who underwent LT (n=41) or LR (n=126) for HCC. IHC markers including alpha-fetoprotein ( AFP), p53, Ki-67, cytokeratin 7 ( CK7), and cytokeratin 19 ( CK19) were compared between the treatment methods in tumor tissue. Results AFP- and p53-negative patients had a significantly higher survival rate than AFP- and p53-positive patients ( AFP: disease-free survival [ DFS] P=.006, overall survival [ OS] P=.016; p53: DFS P=.005, OS P=.038) in the LR group. CK19 was related to DFS ( P=.005), while CK7 ( P=.014) and CK19 ( P=.06) were related to OS in the LT group. When we combined factors that were significant in both groups ( LR: AFP and p53, LT: CK7 and CK19), all-negative patients had a higher survival rate ( LR: DFS P=.025, OS P=.043, LT: DFS P=.034, OS P=.008). Conclusion p53 and AFP were predictors for poor prognosis of HCC after LR; CK7 and CK19 could be predictors for poor prognosis of patients with HCC after LT. [ABSTRACT FROM AUTHOR]