부산대학교 도서관

The article focuses on piebaldism, a rare autosomal dominant disorder, resulting from mutations of the kit proto-oncogene. The kit proto-oncogene encodes the cell-surface receptor transmembrane tyrosine kinase for the steel factor, an embryonic growth factor. The disorder is characterized by the congenital absence of melanocytes in affected areas of the skin and hair, due to mutations of the kit proto-oncogene, which affects the differentiation and migration of melanoblasts. Treatments like grafting and phototherapy may be tried.