학술논문
Using a Polygenic Score to Predict the Risk of Developing Primary Osteoporosis.
Document Type
Article
Author
Source
Subject
*DISEASE risk factors
*BONE density
*OSTEOPOROSIS
*METABOLIC bone disorders
*TERIPARATIDE
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Language
ISSN
1661-6596
Abstract
Osteoporosis (OP) is a multifactorial bone disease belonging to the metabolic osteopathies group. Using the polygenic score (PGS) approach, we combined the effects of bone mineral density (BMD) DNA loci, affecting osteoporosis pathogenesis, based on GEFOS/GENOMOS consortium GWAS meta-analysis. We developed models to predict the risk of low fractures in women from the Volga-Ural region of Russia with efficacy of 74% (AUC = 0.740; OR (95% CI) = 2.9 (2.353–3.536)), as well as the formation of low BMD with efficacy of 79% (AUC = 0.790; OR (95% CI) = 3.94 (2.993–5.337)). In addition, we propose a model that predicts fracture risk and low BMD in a comorbid condition with 85% accuracy (AUC = 0.850; OR (95% CI) = 6.6 (4.411–10.608)) in postmenopausal women. [ABSTRACT FROM AUTHOR]