학술논문
Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide.
Document Type
Article
Author
Source
Subject
*HYDRAZONES
*HYDROXYBENZOIC acid
*X-ray diffraction
*CHEMICAL synthesis
*NEUTROPHILS
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Language
ISSN
1070-3632
Abstract
A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin Е and(or) elastase of human neutrophils has been determined. [ABSTRACT FROM AUTHOR]