학술논문
Preparation and characterization of bi-layered polycaprolactone/polyurethane nanofibrous scaffold loaded with titanium oxide and curcumin for wound dressing applications.
Document Type
Article
Author
Source
Subject
*POLYCAPROLACTONE
*TITANIUM oxides
*CURCUMIN
*POLYURETHANES
*STAINS & staining (Microscopy)
*TRANSMISSION electron microscopy
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Language
ISSN
0947-8396
Abstract
In today's world, wound healing is becoming a challenge for clinical institutes. In this study, nanofibrous scaffolds were prepared using poly(ε-caprolactone) (PCL) and polyurethane (PU) as mat scaffolds. Also by adding titanium dioxide (TiO2) and curcumin, a bi-layered nanocomposite scaffold was fabricated using the electrospinning technique. The obtained scaffolds were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), tensile analysis, porosity, and water vapor transmission rate (WVTR). MTT and DAPI staining were used to prove the biocompatibility and cell attachment of the nanofibers. The PCL/TiO2 scaffold can hinder both the Gram-negative and Gram-positive bacteria through direct contact with them. This study showed that the bi-layered nanocomposite scaffold has the most significant effect on wound healing. [ABSTRACT FROM AUTHOR]