학술논문
Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies.
Document Type
Article
Author
Zendt, Mackenzie; Carrillo, Fausto A. Bustos; Kelly, Sophie; Saturday, Taylor; DeGrange, Maureen; Ginigeme, Anita; Lurline Wu; Callier, Viviane; Ortega-Villa, Ana; Faust, Mondreakest; Chang-Rabley, Emma; Bugal, Kara; Kenney, Heather; Khil, Pavel; Jung-Ho Youn; Osei, Gloria; Regmi, Pravesh; Anderson, Victoria; Bosticardo, Marita; Daub, Janine
Source
Subject
*IMMUNOGLOBULINS
*COVID-19 pandemic
*SARS-CoV-2
*IMMUNOGLOBULIN G
*IMMUNE response
*COVID-19 vaccines
*FC receptors
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Language
ISSN
2375-2548
Abstract
The article focuses on characterizing the immune response to COVID-19 vaccines in individuals with various immunodeficiencies. It is discussed that the study, conducted on 195 immune-deficient/disordered people (IDP) and 35 healthy volunteers (HVs), revealed that despite high seroconversion rates, median antispike immunoglobulin G levels in IDP never exceeded one-third of HV levels and the study found that the efficacy of additional vaccinations, especially against the Omicron BA.1 variant.