부산대학교 도서관

We present a novel algorithm, implemented in the software ARGinfer, for probabilistic inference of the Ancestral Recombination Graph under the Coalescent with Recombination. Our Markov Chain Monte Carlo algorithm takes advantage of the Succinct Tree Sequence data structure that has allowed great advances in simulation and point estimation, but not yet probabilistic inference. Unlike previous methods, which employ the Sequentially Markov Coalescent approximation, ARGinfer uses the Coalescent with Recombination, allowing more accurate inference of key evolutionary parameters. We show using simulations that ARGinfer can accurately estimate many properties of the evolutionary history of the sample, including the topology and branch lengths of the genealogical tree at each sequence site, and the times and locations of mutation and recombination events. ARGinfer approximates posterior probability distributions for these and other quantities, providing interpretable assessments of uncertainty that we show to be well calibrated. ARGinfer is currently limited to tens of DNA sequences of several hundreds of kilobases, but has scope for further computational improvements to increase its applicability. Author summary: One of the important challenges in population genetics is to reconstruct the historical mutation, recombination, and shared ancestor events that underly a sample of DNA sequences drawn from a population. Aspects of this history can inform us about evolutionary processes, ages of mutations and times of common ancestors, and historical population sizes and migration rates. Performing such inferences is difficult, and progress has been slow over the past two decades. Recently, a new and more efficient way to store sequence data has led to improved simulations and also a fast way to reconstruct some aspects of the history. We augment the new data structure to infer many more details of the history, including the times of events. We also provide approximations of the full probability distributions for all the unknowns, not just plausible values. Because this task is highly challenging, we are limited to relatively small data sets, but we show that our inference algorithm represents an important step forward over those currently available in terms of the accuracy of its inferences. [ABSTRACT FROM AUTHOR]