학술논문
Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin.
Document Type
Journal Article
Source
Subject
Language
ISSN
1080-6040
Abstract
US manufacturers, concerned about bovine spongiform encephalopathy (BSE), ceased marketing bovine heparin in the 1990s. Recent short supplies of safe porcine heparin suggest that reintroducing bovine heparin might benefit public health. We purified heparin from crude bovine extract spiked with BSE agent, removing substantial infectivity and abnormal prion proteins (PrPTSE). [ABSTRACT FROM AUTHOR]