학술논문
Synthesis and Antimicrobial Activities of New Polyhalogenated Benzimidazoles.
Document Type
Article
Author
Source
Subject
*ANTI-infective agents
*BENZIMIDAZOLES
*CHEMICAL synthesis
*HALOGENATION
*ANTIPROTOZOAL agents
*DRUG synergism
*CHEMICAL reactions
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Language
ISSN
0022-152X
Abstract
A series of new polyhalogenated benzimidazoles has been synthesized and their antibacterial and antiprotozoal activity was evaluated. Several of new substituted halogenobenzimidazoles and their 2′-deoxynucleosides showed noteworthy antiprotozoal toxicity particularly against Giardia lamblia. The most potent agents against bacteria and fungi were 4,5,6,7-tetrachlorobenzimidazoles with polyfluoroalkyl chain at position 2 of the heterocyclus. [ABSTRACT FROM AUTHOR]