학술논문
Efficacy and safety of total pancreatectomy with islet autotransplantation: A clinical study in Japan.
Document Type
Article
Author
Shimoda, Masayuki; Chujo, Daisuke; Kurokawa, Toshiaki; Kawabe, Akitsu; Takahashi, Nobuyuki; Ito, Kyoji; Maruyama, Koji; Shinohara, Koya; Ajima, Kumiko; Sugahara, Yzumi; Takaki, Tadashi; Kajio, Hiroshi; Yanase, Mikio; Hinohara, Chihaya; Tokuhara, Makoto; Uemura, Yukari; Edamoto, Yoshihiro; Takemura, Nobuyuki; Matsumoto, Shinichi; Kokudo, Norihiro
Source
Subject
*PANCREATECTOMY
*CHRONIC pancreatitis
*ISLANDS
*AUTOTRANSPLANTATION
*EAST Asians
*GLYCEMIC control
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Language
ISSN
1753-0393
Abstract
The median islet yield was 270 967 islet equivalents (IEQ; range, 116 068-467 042), and the median number of transplanted islets was 4149 IEQ/kg body weight (range, 2038-10 836). The limited number of cases is primarily due to the lack of surgical teams for total pancreatectomy and clinical islet isolation and transplantation.1 Against this background, we established a system of islet transplantation at the clinical level, which is the biggest challenge for autologous islet transplantation in Japan, and recently started performing allogeneic islet transplantations. Total pancreatectomy with islet autotransplantation (TPIAT) is considered for chronic pancreatitis (CP) patients,1 particularly those with hereditary pancreatitis, diffuse small pancreatic duct disease, or previous failed surgery.2,3 In TPIAT, pancreatectomy is performed with the aim of relieving pain and restoring quality of life, followed by islet autotransplantation with the aim of reducing the burden of postoperative diabetes.4 According to the first report from the Collaborative Islet Transplant Registry, more than 800 cases of TPIAT had been performed by 2015, mainly in Europe and the United States (https://citregistry.org/system/files/1st%5fAR%5fAuto.pdf). [Extracted from the article]