학술논문
Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort: a dietary pattern approach.
Document Type
Article
Author
Zamora-Ros, Raul; Cayssials, Valerie; Clèries, Ramon; Torrents, Maria; Byrnes, Graham; Weiderpass, Elisabete; Sandström, Maria; Almquist, Martin; Boutron-Ruault, Marie-Christine; Tjønneland, Anne; Kyrø, Cecilie; Katzke, Verena A.; Le Cornet, Charlotte; Masala, Giovanna; Krogh, Vittorio; Iannuzzo, Gabriella; Tumino, Rosario; Milani, Lorenzo; Skeie, Guri; Ubago-Guisado, Esther
Source
Subject
*BEVERAGES
*CONFIDENCE intervals
*DRINKING (Physiology)
*THYROID gland tumors
*REGRESSION analysis
*RISK assessment
*RESEARCH funding
*FACTOR analysis
*DESCRIPTIVE statistics
*DISEASE risk factors
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Language
ISSN
1436-6207
Abstract
Background: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HRQ4vs.Q1 = 0.75; 95% CI:0.60–0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HRQ4vs.Q1 = 1.26; 95% CI:0.99–1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR100mL/d = 1.05; 95% CI:1.00–1.11), especially with papillary TC risk (HR100mL/d = 1.07; 95% CI:1.01–1.13). Similar results were observed with sugary and artificially sweetened beverages. Conclusions: The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages. [ABSTRACT FROM AUTHOR]