학술논문
Immunohistochemical demonstration of bcl-2 protein in ameloblastoma.
Document Type
Journal Article
Author
Source
Subject
*PROTEINS
*IMMUNOHISTOCHEMISTRY
*APOPTOSIS
*GENES
*EPITHELIAL cells
*TEETH
*MONOCLONAL antibodies
*TUMORS
*CELL proliferation
*PROTEIN analysis
*EMBRYONIC physiology
*CELL division
*CELL nuclei
*CYTOPLASM
*EPITHELIUM
*JAW tumors
*ONCOGENES
*STEM cells
*EMBRYOS
*AMELOBLASTOMA
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Language
ISSN
0904-2512
Abstract
The bcl-2 gene is known through its product, bcl-2 protein, which prevents apoptosis, and also by its expression in development, especially in sites characterized by epithelial-mesenchymal interactions. In the developing tooth germ, bcl-2-protein is expressed in the epithelial component. In this study, we examined the expression of bcl-2 protein immunohistochemically in 25 ameloblastomas using a monoclonal antibody against anti-human bcl-2 oncoprotein. In all 25 cases, bcl-2 protein was found mainly in the outer layer of tumor cells, whereas the inner cells (stellate reticulum-like cells and squamoid cells) were negative. The bcl-2 protein is therefore thought to play a role in maintaining the stem-cell population in the peripheral layers of the tumor nests from which proliferating cells can be recruited. [ABSTRACT FROM AUTHOR]