학술논문

Imatinib for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation.
Document Type
Article
Source
Bone Marrow Transplantation. Sep2015, Vol. 50 Issue 9, p1250-1252. 3p. 1 Color Photograph, 1 Graph.
Subject
*HEMATOPOIETIC stem cell transplantation
*TRANSPLANTATION of organs, tissues, etc.
*BRONCHIOLITIS
*PROTEIN-tyrosine kinase inhibitors
*ADRENOCORTICAL hormones
*IMMUNOSUPPRESSIVE agents
Language
ISSN
0268-3369
Abstract
The article presents a study which describes two patient conditions following allogeneic hematopoietic stem cell transplantations (allo-SCT) who develop biopsy-proven bronchiolitis obliterans (BO) that responded well with tyrosine kinase inhibitors (TKIs). It implies that developed BO responds poorly to corticosteroids or immunosuppressants. It recommends that new treatment options are urgently needed to inhibit the progression of BO.