학술논문
Importance of DMSA stability, its consequence for Sn(DMSA) complex formation and relevance to Tc-DMSA radipharmacs preparation.
Document Type
Article
Author
Source
Subject
*SUCCINIC acid
*STABILITY (Mechanics)
*HYDROGEN-ion concentration
*TIN compounds
*OXIDATION
*FUMARATES
*NUCLEAR reactions
*RADIOPHARMACEUTICALS
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Language
ISSN
0236-5731
Abstract
The dimercaptosuccinic acid (DMSA) stability at pH = 3.8, 7.1, 8.8 and the interaction with SnCl·2HO were investigated. The degradation of DMSA is the most significant at alkali pH. There where observed oxidized and dimerized forms of DMSA and fumaric acid presence. Progress of instability is less substantial and slower under neutral reaction conditions. At acidic pH the concentration of soluble DMSA decreases with the time. The ligand forms with SnCl complex under alkali pH = 8.8 and its chemical formula was determined as Sn(DMSA) [ABSTRACT FROM AUTHOR]